Hubungan Gejala Kolesistolitiasis dengan Kejadian Gastritis dan Karakteristiknya

Hardianto Setiawan* -  Universitas Tarumanagara, Indonesia
Rio Saputra -  Rumah Sakit Siloam Kebon Jeruk, Indonesia
Yohanes Firmansyah -  Universitas Tarumanagara, Indonesia
Fernando Nathaniel -  Universitas Tarumanagara, Indonesia
Giovanno Sebastian Yogie -  Universitas Tarumanagara, Indonesia



Cholecystolithiasis and gastritis are both very common conditions in the modern era, and they can occur together. The relationship between cholecystolithiasis and gastritis in terms of their characteristics and clinical implications is not yet fully understood. This study aims to determine the association between cholecystolithiasis symptoms and the occurrence of gastritis as observed through endoscopy, along with the analysis of their characteristics. This study employed a cross-sectional design with a total of 114 participants obtained from medical records of several hospitals in Jakarta from January 2020 to 2023. Data analysis was conducted using Pearson Chi-Square test with Yates Correction and Fisher's exact test to test the hypotheses. The results of the study showed no significant association between gender, H. pylori infection, and bile reflux with positive endoscopy results for gastritis in patients with cholecystolithiasis (p > 0.05). Clinical exploration revealed that male gender, H. pylori infection, and the presence of bile reflux symptoms did have a higher risk for positive endoscopy results [PR: 1.152 (0.996 - 1.333) vs. 1.169 (1.080 - 1.264) vs. 1.165 (1.078 - 1.258)]. There was a significant association between gastrointestinal symptoms and positive endoscopy results (PR: 1.802, p-value < 0.001). Abdominal pain obtained a 100% value for positive endoscopy results of gastritis in patients diagnosed with cholecystolithiasis. There is no significant association between gender, H. pylori infection, and bile reflux with the occurrence of gastritis in patients with cholecystolithiasis. However, there is a significant association between gastrointestinal symptoms and positive endoscopy results, with abdominal pain being the most strongly associated symptom.


Keywords : Cholecystolithiasis, Gastritis, Risk factors





Kolesistolitiasis dan gastritis keduanya merupakan kondisi yang sangat umum di era modern dan kejadian tersebut dapat terjadi secara bersamaan. Hubungan antara kolesistolitiasis dengan gastritis ditinjau dari karakteristiknya serta implikasi klinisnya masih belum sepenuhnya dipahami. Studi ini bertujuan untuk mengetahui hubungan gejala kolesistolitiasis dengan kejadian gastritis yang ditinjau dari endoskopi beserta analisis karakteristiknya. Penelitian ini menggunakan desain penelitian potong lintang dengan total 114 partisipan yang diperoleh dari rekam medis dari beberapa rumah sakit di Jakarta periode januari 2020 hingga 2023. Analisis data dilakukan dengan menggunakan uji statistik Pearson Chi Square with Yates Correction dan Fisher Exact untuk menguji hipotesis. Hasil penelitian menunjukan tidak ada hubungan yang signifikan antara jenis kelamin, infeksi H.pylori, dan bile reflux  dengan hasil endoskopi positif untuk gastritis pada pasien kolesistolitiasis (p > 0,05). Penelusuran secara klinis mengungkapkan bahwa jenis kelamin laki-laki, infeksi H. pylori dan adanya gejala bile reflux  memang memiliki risiko lebih tinggi untuk hasil endoskopi positif [PR: 1,152 (0,996 - 1,333) v.s 1,169 (1,080 - 1,264) v.s. 1,165 (1,078 - 1,258)]. Terdapat hubungan yang signifikan antara gejala gastrointestinal dengan hasil endoskopi yang positif (PR: 1,802, nilai p <0,001). Keluhan nyeri perut mendapatkan nilai 100% untuk hasil endoskopi positif gastritis pada pasien telah terdiagnosis kolesistolitiasis. Tidak ada hubungan yang signifikan antara jenis kelamin, infeksi h.pylori, dan bile reflux  dengan kejadian gastritis pada pasien kolesistolitiasis. Namun terdapat hubungan signifikan antara gejala gastrointestinal dengan hasil endoskopi yang positif, dimana keluhan nyeri perut memiliki kejadian yang paling kuat.


Kata Kunci: Faktor Risiko, Gastritis, Kolesistolitiasis

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