Probiotics' Function in Enhancing the Health of Periodontal Tissue : A Comprehensive Analysis of Recent Data
Sari
Periodontal disease is one of the common dental and oral health problems and can cause damage to the dental supporting tissue if not treated properly. Various approaches have been developed to prevent and treat this disease, one of which is the use of probiotics. Probiotics are known to help maintain the balance of the oral microbiota, reduce inflammation, and inhibit the growth of pathogenic bacteria that contribute to periodontal disease. This study aims to review the role of probiotics in improving periodontal tissue health based on recent studies. The method used in this review involved searching and selecting journals from various scientific databases relevant to the topic of probiotics and periodontal health. The inclusion criteria included studies that addressed the effects of probiotics on periodontal health, while the exclusion criteria were applied to studies with methodologies that were unclear or irrelevant to the focus of the study. The results of the review show that probiotics, especially from the genera Lactobacillus and Bifidobacterium, have the potential to reduce gingival inflammation, reduce the depth of periodontal pockets, and improve overall periodontal health. The main mechanisms found involve competition with pathogenic bacteria, modulation of immune responses, as well as the production of natural antimicrobial compounds. In conclusion, probiotics have the potential to be an effective adjunct therapy in maintaining the health of periodontal tissue. However, more research is needed to determine the optimal dosage, duration of use, as well as its long-term effectiveness in periodontal care.
Kata Kunci
Teks Lengkap:
Download Artikel (English)Referensi
Abdullah, H. N. and Rashid, S. K. (2022). Probiotic bacterial effects on the treatment of chronic periodontitis patients: a double-blind study. The Journal of University of Duhok, 25(2), 380-388. https://doi.org/10.26682/sjuod.2022.25.2.35
Agossa, K., Dubar, M., Lemaire, G., Blaizot, A., Catteau, C., Bocquet, E., Nawrocki, L., Boyer, E., Meuric, V., & Siepmann, F. (2022). Effect of Lactobacillus reuteri on gingival inflammation and composition of the oral microbiota in patients undergoing treatment with fixed orthodontic appliances: Study protocol of a randomized control trial. Pathogens, 11(112). https://doi.org/10.3390/pathogens11020112
Angarita-Díaz, M. del P., Fong, C., & Medina, D. (2024). Bacteria of healthy periodontal tissues as candidates of probiotics: A systematic review. European Journal of Medical Research, 29(1), Article 1908. https://doi.org/10.1186/s40001-024-01908-2
Apriliani, K. P., Pamukas, N. A., & Mulyadi, M. (2024). Pengaruh pemberian probiotik rabal pada pakan dengan dosis berbeda terhadap laju pertumbuhan benih ikan baung (hemibagrus nemurus) menggunakan sistem resirkulasi. Ilmu Perairan (Aquatic Science), 12(1), 107. https://doi.org/10.31258/jipas.12.1.p.107-118
Ausenda, F., Barbera, E., Cotti, E., Romeo, E., Natto, Z. S., & Valente, N. A. (2023). Clinical, microbiological and immunological short, medium and long-term effects of different strains of probiotics as an adjunct to non-surgical periodontal therapy in patients with periodontitis. systematic review with meta-analysis. Japanese Dental Science Review, 59, 62-103. https://doi.org/10.1016/j.jdsr.2023.02.001
Babina, K., Salikhova, D., Makeeva, I., Zaytsev, A., Sokhova, I., Musaeva, S., Polyakova, M., & Novozhilova, N. (2024). A three-month probiotic (the Streptococcus salivarius M18 strain) supplementation decreases gingival bleeding and plaque accumulation: A randomized clinical trial. Dentistry Journal, 12(7), 222. https://doi.org/10.3390/dj12070222
Blais, L., Auclair-Ouellet, N., Tremblay, A., & Binda, S. (2025). Effect of the Darolac® (Oralis SB®) probiotic formulation on oral health: A narrative review. Microorganisms, 13(2), 408. https://doi.org/10.3390/microorganisms13020408
Butera, A., Gallo, S., Pascadopoli, M., Taccardi, D., & Scribante, A. (2022). Home oral care of periodontal patients using antimicrobial gel with postbiotics, lactoferrin, and Aloe barbadensis leaf juice powder vs. conventional chlorhexidine gel: A split-mouth randomized clinical trial. Antibiotics, 11(1), 118. https://doi.org/10.3390/antibiotics11010118
Domínguez, L., Cepeda, J., Sánchez, L., Márquez, R., & Aranda Romo, S. (2018). Evaluation of the clinical effect of a probiotic mouthwash in the treatment of generalized marginal chronic gingivitis: A randomized pilot study. J Oral Res, 7(4), 134-140. https://doi.org/10.17126/joralres.2018.032
Ferrer, M. D., López-López, A., Nicolescu, T., Perez-Vilaplana, S., Boix-Amorós, A., Dzidic, M., Garcia, S., Artacho, A., Llena, C., & Mira, A. (2020). Application of the probiotic Streptococcus dentisani improves clinical and microbiological parameters associated with oral health. Frontiers in Cellular and Infection Microbiology, 10, 465. https://doi.org/10.3389/fcimb.2020.00465
Gao, L., Kuraji, R., Zhang, M. J., Martínez, A., Radaic, A., Kamarajan, P., … & Kapila, Y. L. (2022). Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome. NPJ Biofilms and Microbiomes, 8(1). https://doi.org/10.1038/s41522-022-00307-x
Garcia, M. N., et al. (2020). “Oral Probiotics and Their Role in Periodontal Health: A Narrative Review.” Journal of Dental Research, 99(10), 1150–1158.
Gheisary, Z., Mahmood, R., shivanantham, A. H., Liu, J., Lieffers, J., Papagerakis, P., … & Papagerakis, S. (2022). The clinical, microbiological, and immunological effects of probiotic supplementation on prevention and treatment of periodontal diseases: a systematic review and meta-analysis. Nutrients, 14(5), 1036. https://doi.org/10.3390/nu14051036
Goloshchapov, O. V., Чухловин, А. Б., Bug, D. S., Polev, D. E., Kosarev, O. V., Klementeva, R. V., … & Moiseev, I. (2024). Safety, feasibility, and advantages of oral microbiota transplantation: the first clinical case. Journal of Pediatric Hematology/Oncology, 46(6), 287-296. https://doi.org/10.1097/mph.0000000000002896
Goyal, N., Shamanna, P. U., Varughese, S. T., Abraham, R., Antony, B., & Emmatty, R. (2019). Effects of amine fluoride and probiotic mouthwash on levels of Porphyromonas gingivalis in orthodontic patients: A randomized controlled trial. Journal of Indian Society of Periodontology. https://doi.org/10.4103/jisp.jisp_551_18
Hadj-Hamou, R., Senok, A. C., Athanasiou, A. E., & Kaklamanos, E. G. (2020). Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review. BMC Oral Health, 20, 126. https://doi.org/10.1186/s12903-020-01109-3
Han, N., Jia, L., Guo, L., Su, Y., Luo, Z., Du, J., Mei, S., & Liu, Y. (2020). Balanced oral pathogenic bacteria and probiotics promoted wound healing via maintaining mesenchymal stem cell homeostasis. Stem Cell Research & Therapy, 11(1), 61. https://doi.org/10.1186/s13287-020-1569-2
Hardan, L., Bourgi, R., Cuevas‐Suárez, C. E., Flores-Rodríguez, M., Omaña-Covarrubias, A., Nicastro, M., … & Łukomska−Szymańska, M. (2022). The use of probiotics as adjuvant therapy of periodontal treatment: a systematic review and meta-analysis of clinical trials. Pharmaceutics, 14(5), 1017. https://doi.org/10.3390/pharmaceutics14051017
Jansen, P. M., Abdelbary, M. M. H., & Conrads, G. (2021). A concerted probiotic activity to inhibit periodontitis-associated bacteria. Plos One, 16(3), e0248308. https://doi.org/10.1371/journal.pone.0248308
Kapila, Y. L., Gao, L., Kuraji, R., Zhang, M. J., Martínez, A., Kamarajan, P., … & Sailani, M. R. (2021). Nisin probiotic prevents periodontal disease and inflammation while promoting periodontal regeneration and a shift toward a healthy microbiome/virome.. https://doi.org/10.21203/rs.3.rs-599805/v1
Kavitha, M., Prathima, G. S., Anusha, D., Kengadaran, S., Gayathri, K., & Vinothini, V. (2022). Evaluation of the efficacy of plaque reduction and gingival health among 6–12 years old school children before and after a short-term daily intake of probiotic lozenge – A comparative study. Indian Journal of Dental Research, 33(4), 184–187. https://doi.org/10.4103/ijdr.IJDR_232_20
Kim, H., et al. (2022). “Impact of Probiotic Supplementation on Oral Microbiota and Periodontal Health: A Systematic Review and Meta-Analysis.” Journal of Periodontal Research, 57(4), 456–468.
Kumar, R., et al. (2023). “Efficacy of Probiotic Therapy in the Management of Periodontitis: A Systematic Review.” Journal of Clinical Periodontology, 50(3), 234–245.
LI, J., Zhao, G., Zhang, H., & Zhu, F. (2023). Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis. Beneficial Microbes, 14(2), 95-108. https://doi.org/10.3920/bm2022.0056
Liang, W., Feng, Y., Yang, D., Qin, J., Zhi, X., Wu, W., & Jie, Q. (2023). Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus. Molecular Medicine, 29, Article 716. https://doi.org/10.1186/s10020-023-00716-4
Mahdizade Ari, M., Mirkalantari, S., Darban-Sarokhalil, D., Darbandi, A., Razavi, S., & Talebi, M. (2024). Investigating the antimicrobial and anti-inflammatory effects of Lactobacillus and Bifidobacterium spp. on cariogenic and periodontitis pathogens. Frontiers in Microbiology, 15, 1383959. https://doi.org/10.3389/fmicb.2024.1383959
Manuballa, S., Abdelmaseh, M., Tasgaonkar, N., Frias, V., Hess, M. W., Crow, H., … & Seshadri, M. (2020). Managing the oral health of cancer patients during the covid-19 pandemic: perspective of a dental clinic in a cancer center. Journal of Clinical Medicine, 9(10), 3138. https://doi.org/10.3390/jcm9103138
Minić, I., Pejčić, A., & Bradić‐Vasić, M. (2021). Effect of the local probiotics in the therapy of periodontitis a randomized prospective study. International Journal of Dental Hygiene, 20(2), 401-407. https://doi.org/10.1111/idh.12509
Morales, A., Contador, R., Bravo, J., Carvajal, P., Silva, N., Strauß, F. J., … & Gamonal, J. (2021). Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage iii periodontitis: a pilot randomized controlled clinical trial. BMC Oral Health, 21(1). https://doi.org/10.1186/s12903-020-01276-3
Nguyen, T., Brody, H., Radaic, A., & Kapila, Y. L. (2021). Probiotics for periodontal health—current molecular findings. Periodontology 2000, 87(1), 254-267. https://doi.org/10.1111/prd.12382
Oktafiani, M., Fransiska, A., & Yohana, N. (2023). Pengaruh minuman probiotik lactobacillus casei shirota strain terhadap pelepasan ion nikel braket stainless steel. Andalas Dental Journal, 11(1), 21-27. https://doi.org/10.25077/adj.v11i1.228
Omori, M., Kato‐Kogoe, N., Sakaguchi, S., Komori, E., Inoue, K., Yamamoto, K., … & Ueno, T. (2023). Characterization of oral microbiota following chemotherapy in patients with hematopoietic malignancies. Integrative Cancer Therapies, 22. https://doi.org/10.1177/15347354231159309
Parra-Rojas, S., Spanemberg, J. C., Díaz-Robayna, N. d. M., Peralta-Mamani, M., & Velázquez-Cayón, R. T. (2024). Assessing the cost-effectiveness of photobiomodulation for oral mucositis prevention and treatment: a systematic review. Biomedicines, 12(10), 2366. https://doi.org/10.3390/biomedicines12102366
Puzhankara, L., Banerjee, A., Chopra, A., Ramanarayanan, V., & Kedlaya, M. N. (2023). Effectiveness of probiotics compared to antibiotics to treat periodontal disease: systematic review. Oral Diseases, 30(5), 2820-2837. https://doi.org/10.1111/odi.14781
Retamal-Valdes, B., Teughels, W., Oliveira, L. M., da Silva, R. N., Fritoli, A., Gomes, P., Soares, G. M. S., Temporão, N., Furquim, C. P., Duarte, P. M., Doyle, H., Faveri, M., Figueiredo, L. C., & Feres, M. (2021). Clinical, microbiological, and immunological effects of systemic probiotics in periodontal treatment: Study protocol for a randomized controlled trial. Trials, 22, 283. https://doi.org/10.1186/s13063-021-05246-0
Sachelarie, L., Scrobota, I., Romanul, I., Iurcov, R., Potra Cicalau, G. I., & Todor, L. (2025). Probiotic therapy as an adjuvant in the treatment of periodontal disease: An innovative approach. Medicina, 61(1), 126. https://doi.org/10.3390/medicina61010126
Şahin, T., Akca, G., & Özmeriç, N. (2024). The role of probiotics for preventing dysbiosis in periodontal disease: A randomized controlled trial. Turkish Journal of Medical Sciences, 54(1), Article 40. https://doi.org/10.55730/1300-0144.5798
Sahni, P., Punyani, S. R., Jain, S., Nayak, K. C., Charan, A., & Karwasra, K. (2020). Oral alterations and oral health‐related quality of life assessment in patients undergoing chemotherapy at a tertiary care center. Special Care in Dentistry, 40(5), 450-456. https://doi.org/10.1111/scd.12499
Schmitter, T., Fiebich, B. L., Fischer, J. T., Gajfulin, M., Larsson, N., Rose, T., & Goetz, M. R. (2018). Ex vivo anti-inflammatory effects of probiotics for periodontal health. Journal of Oral Microbiology, 10(1), 1502027. https://doi.org/10.1080/20002297.2018.1502027
Sharma, H., Ruikar, M., & Verma, S. (2024). Probiotic supplementation for periodontal diseases - An umbrella review. Indian Journal of Dental Research, 35, 339-348. https://doi.org/10.4103/ijdr.ijdr_905_23
Shi, Q., Sun, L., Gao, J., Li, F., Chen, D., Shi, T., Tan, Y., Chang, H., Liu, X., Kang, J., Lu, F., Huang, Z., & Zhao, H. (2024). Effects of sodium lauryl sulfate and postbiotic toothpaste on oral microecology. Journal of Oral Microbiology, 16(1), Article 2372224. https://doi.org/10.1080/20002297.2024.2372224
Smith, J. A., et al. (2021). “Modulation of Host Immune Response by Probiotics in Periodontal Disease.” Periodontology 2000, 86(1), 120–135.
Suratri, M. A. L. (2020). Pengaruh hipertensi terhadap kejadian penyakit jaringan periodontal (periodontitis) pada masyarakat indonesia (data riskesdas 2018). Buletin Penelitian Kesehatan, 48(4), 227-234. https://doi.org/10.22435/bpk.v48i4.3516
Vives-Soler, A. and Küstner, E. C. (2020). Effect of probiotics as a complement to non-surgical periodontal therapy in chronic periodontitis: a systematic review. Medicina Oral Patología Oral Y Cirugia Bucal, 0-0. https://doi.org/10.4317/medoral.23147
Wen, S., Brito, L., Santander, J., & Conteras, G. (2023). Update on the treatment of chemotherapy and radiotherapy- induced buccal mucositis: a systematic review. Acta Odontológica Latinoamericana, 36(1), 3-14. https://doi.org/10.54589/aol.36/1/3
Wijayanti, D. A., Herawati, D., Karina, V. M., & Murdiastuti, K. (2024). Chitosan collagen hydrogel: a potential scaffold biomaterial for periodontal regenerative treatment. Interdental Jurnal Kedokteran Gigi (IJKG), 20(1), 124-132. https://doi.org/10.46862/interdental.v20i1.8663
Yang, S., He, J., Shi, J., Xie, L., Liu, Y., Xiong, Y., & Liu, H. (2024). Characteristics of intestinal microbiota in preterm infants and the effects of probiotic supplementation on the microbiota. Frontiers in Microbiology, 15, Article 1339422. https://doi.org/10.3389/fmicb.2024.1339422.
DOI: https://doi.org/10.33024/mnj.v7i8.21445
Refbacks
- Saat ini tidak ada refbacks.
Penerbit: Universitas Malahayati
Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License