Vitamin Antioksidan Sebagai Terapi Potensial Untuk Mengurangi Nyeri Pada Endometriosis

Rista Dwi Hermilasari, Harry Allan Papendang

Sari


Endometriosis termasuk penyakit ginekologi yang bersifat kronis yang rentan dialami oleh wanita usia reproduktif. Neuroinflamasi pada endometriosis berkaitan dengan adanya nyeri pelvis kronis. Salah satu permasalahan infertilitas pada wanita biasanya disebabkan oleh  endometriosis. Penurunan kadar antioksidan ditemukan secara umum pada penderita endometriosis. Vitamin merupakan senyawa yang mengandung tinggi antioksidan dan memiliki potensi suportif dalam inhibisi produksi ROS dan stress oksidatif. Tujuan dari penelitian adalah mengkaji efektivitas vitamin antioksidan dalam meredakan nyeri pada endometriosis. Penelitian ini adalah Narrative Literature Review yang diambil dari database PubMed, Google Scholar dan ProQuest dengan kata kunci kata kunci vitamin, antioxidant, vitamin B, vitamin C, vitamin D, vitamin E, endometriosis, endometrioma, pelvic pain. Artikel dipilih memenuhi kriteria inklusi dan eksklusi yang telah ditentukan. Pada review ini didapatkan bahwa suplementasi vitamin B2, B6,  B12, vitamin C, vitamin D dan vitamin E yang diberikan pada wanita yang menderita endometriosis dapat mengurangi gejala nyeri endometriosis secara signifikan. Oleh karena itu, konsumsi mikronutrien seperti vitamin antioksidan sangat direkomendasikan sebagai terapi alternatif dalam mengobati endometriosis karena memiliki efek antiinflamasi, antiangiogenik, anti proliferasi, dan imunomodulator.


Kata Kunci


Endometriosis; Nyeri Pelvis; Terapi; Vitamin

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Referensi


Abramiuk, M., Mertowska, P., Frankowska, K., & Swiechowska-starek, P. (2024). How can selected dietary ingredients influence the development and progression of endometriosis? Nutrients, 16(1), 154.

Al-naggar, M. A., Saeed, I., Abdelfattah, A. T., & Al-naggar, M. A. (2022). Role of antioxidants (vitamin E and vitamin C) supplementation for management of chronic pelvic pain related to endometriosis. Zagazig University Medical Journal, 28(6), 1269–1273.

Alam, F., Shahid, M., Riffat, S., Zulkipli, I., Syed, F., Ashraf, M., & Rehman, R. (2023). SIRT1 and antioxidants in infertile females: exploration of the role of vitamin D. PLoS ONE, 18(7), e0287727. https://doi.org/10.1371/journal.pone.0287727

Amini, L., Chekini, R., Nateghi, M. R., Haghani, H., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2021). The effect of combined vitamin C and vitamin E supplementation on oxidative stress markers in women with endometriosis: a randomized, triple-blind placebo-controlled clinical trial. Pain Research and Management, 2021, 5529741.

Bahat, P., Ayhan, I., Ozdemir, E., Inceboz, Ü., & Oral, E. (2021). Dietary supplements for treatment of endometriosis: a review. Acta Biomed, 93(1), e2022159. https://doi.org/10.23750/abm.v93i1.11237

Bayu, P., & Wibisono, J. (2024). Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: a systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 19(5), e0301867. https://doi.org/10.1371/journal.pone.0301867

Chen, Y., & Li, T. (2025). Unveiling the mechanisms of pain in endometriosis: comprehensive analysis of inflammatory sensitization and therapeutic potential. Int J Mol Sci, 26(4), 1770.

Clower, L., Fleshman, T., & Geldenhuys, W. J. (2022). Targeting Oxidative Stress Involved in Endometriosis and Its Pain. Biomolecules,

, 1055.

Didier, A. J., Stiene, J., Fang, L., Creeden, J. F., Watkins, D., & Dworkin, L. D. (2023). Antioxidant and anti-tumor effects of dietary vitamins A, C, and E. Antioxidants (Basel), 12(3), 632.

Donnez, J., Taylor, H., Taylor, R., Akin, M., Tatarchuk, T., Wilk, K., Gotteland, J., Lecomte, V., & Beste, E. (2020). Treatment of endometriosis- associated pain with linzagolix, an oral gonadotropin-releasing hormone – antagonist: a randomized clinical trial. Fertil Steril, 114(1), 44–55.

https://doi.org/10.1016/j.fertnstert.2020.02.114

Effendi, Y., Ocviyanti, D., Amin, R., Hafy, Z., & Partan, R. U. (2022). Gynaecologic history during adolescence to predict endometriosis earlier. Bioscientia Medicina, 6(3), 1515–1522.

Forno, S. D. E. L., Arena, A., Pellizzone, V., Lenzi, J., Raimondo, D., Cocchi, L., Paradisi, R., Youssef, A., Casadio, P., & Seracchioli, R. (2021). Assessment of levator hiatal area using 3D / 4D transperineal ultrasound in women with deep infiltrating endometriosis and superficial dyspareunia treated with pelvic floor muscle physiotherapy : randomized controlled trial. Ultrasound Obstet Gynecol, 57, 726–732. https://doi.org/10.1002/uog.23590

Giano, M., Franco, C., Castrezzati, S., & Rezzani, R. (2023). Involvement of Oxidative Stress and Nutrition in the Anatomy of Orofacial Pain. International Journal of Molecular Sciences, 24, 13128.

Giudice, L. C., As-sanie, S., Ferreira, J. C. A., Becker, C. M., Abrao, M. S., Lessey, B. A., Brown, E., & Dynowski, K. (2022). Articles Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain : two replicate phase 3 , randomised , double-blind , studies ( SPIRIT 1 and 2 ). Lancet, 399, 2267–2279. https://doi.org/10.1016/S0140-6736(22)00622-5

Habib, N., Buzzaccarini, G., Centini, G., Moawad, G. N., Ceccaldi, P., Gitas, G., Alkatout, I., Gullo, G., Terzic, S., & Sleiman, Z. (2022). Impact of lifestyle and diet on endometriosis : a fresh look to a busy corner. Menopause Rev, 21(2), 124–132.

Harada, T., Osuga, T., Suzuki, Y., Fujisawa, M., Fukui, M., & Kitawaki, J. (2022). Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain compared with leuprorelin in Japanese women: a phase 3, randomized, double-blind, noninferiority study. Fertil Steril, 117(3), 583–592.

https://doi.org/10.1016/j.fertnstert.2021.11.013

Hoorsan, H., Simbar, M., Tehrani, F. R., Fathi, F., Mosaffa, N., Riazi, H., Akradi, L., & Nasseri, S. (2022). The effectiveness of antioxidant therapy ( vitamin C ) in an experimentally induced mouse model of ovarian endometriosis. Women’s Health, 18, 1–12. https://doi.org/10.1177/17455057221096218

Kalaitzopoulos, D. R., Samartzis, N., Daniilidis, A., Leeners, B., Makieva, S., Nirgianakis, K., Dedes, I., Metzler, J. M., Imesch, P., & Lempesis, I. G. (2022). Effects of vitamin D supplementation in endometriosis: a systematic review. Reprod Biol Endocrinol, 20, 176. https://doi.org/10.1186/s12958-022-01051-9

Lamceva, J., Uljanovs, R., & Strumfa, I. (2023). The main theories on the pathogenesis of endometriosis. Int. J. Mol. Sci, 24, 4254.

Lee, D., Kim, S. K., Lee, J. R., & Jee, B. C. (2020). Management of endometriosis-related infertility : Considerations and treatment options. Clin. Exp. Reprod. Med., 47(1), 1–11.

Li, S., Chen, B., Sheng, B., & Wang, J. (2020). The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study. Journal of International Medical

Research, 48(5), 1–11. https://doi.org/10.1177/0300060520923492

Marcinkowska, A., & Magdalena, G. (2023). The Role of Dietary Fats in the Development and Treatment of Endometriosis. Life, 13, 654.

Mechsner, S. (2022). Endometriosis, an ongoing pain-step-by-step treatment. Journal of Clinical Medicine, 11(2), 467.

Mehdizadehkashi, A., Rokhgireh, S., Tahermanesh, K., Eslahi, N., Minaeian, S., & Samimi, M. (2021). The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol Endocrinol, 37(7), 640–645. https://doi.org/10.1080/09513590.2021.1878138

Nodler, J. L., Divasta, A. D., Vitonis, A. F., Karevicius, S., Malsch, M., & Sarda, V. (2020). Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized , placebo-controlled trial. Am J Clin Nutr, 112(1), 229–236.

Pessoa, M., Rodrigues, D. F., Vilarino, F. L., Souza, A. De, Munhoz, B., Paiva, S., Vinicius, L., Sousa, D. A., Zaia, V., & Barbosa, C. P. (2020). Clinical aspects and the quality of life among women with endometriosis and infertility: a cross-sectional study. BMC Women’s Health, 20(1), 124.

Piecuch, M., Garbicz, J., Waliczek, M., & Malinowska-borowska, J. (2022). I am the 1 in 10 - What should I Eat? a research review of nutrition in endometriosis. Nutrients, 14(24), 5283.

Qiu, Y., Yuan, S., & Wang, H. (2020). Vitamin D status in endometriosis : a systematic review and meta‑analysis. Arch Gynecol Obstet, 302(1), 141–152. https://doi.org/10.1007/s00404-020-05576-5

Roshanzadeh, G., Sadatmahalleh, S., Moini, A., Mottaghi, A., & Rostami, F. (2023). The relationship between dietary micronutrients and endometriosis: a case-control study. Int J Reprod Biomed, 21(4), 333–342.

Salinas-Asensio, M., Ocón-Hernández, O Mundo-López, A., Fernández-Lao, C., Peinado, F., Padilla-Vinuesa, C., Álvarez-Salvago, F., Postigo-Martín, P., Lozano-Lozano, M., Lara-Ramos, A., Arroyo-Morales, A., & Cantarero-Villanueva, I Artacho-Cordón, F. (2022). “Physio-EndEA” study: a randomized, parallel-group controlled trial to evaluate the effect of a supervised and adapted therapeutic exercise program to improve quality of life in symptomatic women diagnosed with endometriosis. International Journal of Environmental Research and Public Health, 19, 1738.

Saunders, P. T. K., & Horne, A. W. (2021). Endometriosis: etiology, pathobiology, and therapeutic prospects. Cell, 184(11), 2807–2824. https://doi.org/10.1016/j.cell.2021.04.041

Sehsah, F., El-fattah, A., & Saeed, A. (2022). The role of antioxidant supplementation in reducing the endometriosis related chronic pelvic pain in women. Al-Azhar Med J, 51(1), 121–134. https://doi.org/10.21608/amj.2022.212587

Sinbad, O., Folorunsho, A., Olabisi, O., Ayoola, O., & Temitope, E. (2019). Vitamins as antioxidants. J Food Sci Nutr Res, 2(3), 214–235. https://doi.org/10.26502/jfsnr.2642-11000021

Ursache, A., Lozneanu, L., Bujor, I. E., Mandici, C. E., Boiculese, L. V., Irma, A., Bausic, G., Grigore, M., Socolov, D., & Matasariu, D. R. (2024). Vitamin D — The Iceberg in Endometriosis — Review and. Journal of Personalized Medicine, 14, 119.

Velarde, M., Bucu, M., & Habana, M. (2023). Endometriosis as a highly relevant yet neglected gynecologic condition in Asian women. Endocr Connect, 12(11), e230169.

Viana, C., Felipe, V. L., Shivappa, N., Hebert, J. R., Perini, J. A., Brito, P. D. De, Cardoso, J. V., Ferrari, R., Leão, G., & Filho, D. A. (2021). Dietary inflammatory index score and risk of developing endometriosis: a case–control study. Journal of Endometriosis and Pelvic Pain Disorders, 13(1), 32–39. https://doi.org/10.1177/2284026520967599

Wardhana, A. P., & Irwanto, Y. (2023). Effect of genistein on proliferating cell nuclear antigen (PCNA) expression and vascular density in the peritoneum of endometriosis mice model. Asian J Heal Res, 2(3), 5–11.

WHO. (2023). Endometriosis. Accessed on 10 February 2025. https://www.who.int/news-room/fact-sheets/detail/endometriosis

Xu, T., Zhuang, Y., & Cao, H. (2024). The association between vitamin

intake and endometriosis: a cross ‑ sectional study of the NHANES 1999-2006. Reprod Health, 21(1), 158. https://doi.org/10.1186/s12978-024-01895-x




DOI: https://doi.org/10.33024/jikk.v12i10.19705

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