Profil Kadar Low Density Lipoprotein-cholesterol (LDL-c) dan Indeks Massa Tubuh (IMT) pada Penderita Hipertensi Derajat 2

Mutmainnah Abbas, Velinda Sutedjo, Rosdiana Mus




LDL-c is a lipoprotein that plays a role in the formation of lipid fractions, functions as a carrier for cholesterol in urine, and is useful for the synthesis of membranes and steroid hormones. Increased levels of lipids in the blood can also lead to increased blood pressure that will develop into hypertension. The purpose of this study is to determine the profile of LDL levels in patients with degree 2 hypertension. This research was based on an observational-descriptive approach. This research was done at the Parahita Clinic in Makassar. The subjects of this research were 25 people, obtained with the total sampling technique based on the research. Based on the result of research from 25 people as respondents, the average low-density lipoprotein (LDL) levels tended to be 139 mg/dL. Increased LDL levels in patients with degree 2 hypertension are due to unhealthy diet and physical activity patterns and also due to the presence of variations in IMT that tend to increase.


Keywords: Hypertension, Low-density Lipoprotein, Body Mass Index





LDL-c merupakan salah satu lipoprotein yang berfungsi untuk mentranspor kolesterol menuju jaringan perifer serta mensintesis membran dan hormon steroid. Meningkatnya kadar lipid di dalam darah juga dapat menyebabkan peningkatan tekanan darah yang semakin lama akan berkembang menjadi hipertensi. Penelitian ini bertujuan untuk mengetahui profil kadar LDL  pada penderita hipertensi derajat 2. Metode penelitian deskriptif analitik dengan desain Cross Sectional Study yang dilakukan di Klinik Parahita Kota Makassar. Subjek penelitian berjumlah 25 orang yang diperoleh melalui teknik total sampling berdasarkan kriteria subjek penelitian. Berdasarkan hasil penelitian pada 25 orang responden, diperoleh rata-rata kadar LDL (Low Density Lipoprotein) cenderung meningkat yaitu 139 mg/dL. Peningkatan kadar LDL pada penderita hipertensi derajat 2 disebabkan oleh pola diet dan aktivitas fisik yang tidak sehat dan juga disebabkan oleh adanya variasi IMT yang cenderung meningkat.


Kata Kunci: Hipertensi, Low Density Lipoprotein, Indeks Massa Tubuh

Teks Lengkap:

Download Artikel


Agustiyanti, P. N., Pradigdo, S. F., & Aruben, R. (2017). Hubungan Asupan Makanan, Aktivitas Fisik dan Penggunaan Kontrasepsi Hormonal dengan Kadar Kolesterol Darah. Jurnal Kesehatan Masyarakat, 5.

Amanda, D., & Martini, S. (2018). The Relationship between Demographical Characteristic and Central Obesity with Hypertension. Jurnal Berkala Epidemiologi, 6(1), 43.

Djasang, S. (2019). Analisis Hasil Pemeriksaan Kadar Low-Density Lipoprotein (LDL-Chol) Metode Direk Dan Indirek. JurnalMedia Analis Kesehatan, 8(2),43.

Feryadi, R., Sulastri, D., & Kadri, H. (2014). Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012. Jurnal KesehatanAndalas,3(2).

Han, T. S., Correa, E., Lean, M. E. J., Lee, D. M., O’Neill, T. W., Bartfai, G., Forti, G., Giwercman, A., Kula, K., Pendleton, N., Punab, M., Rutter, M. K., Vanderschueren, D., Huhtaniemi, I. T., Wu, F. C. W., & Casanueva, F. F. (2017). Changes in prevalence of obesity and high waist circumference over four years across European regions: The European male ageing study (EMAS). Endocrine, 55(2), 456–469.

Kapetanakis, V. V., Rudnicka, A. R., Wathern, A. K., Lennon, L., Papacosta, O., Cook, D. G., Wannamethee, S. G., Whincup, P. H., & Owen, C. G. (2014). Adiposity in Early, Middle and Later Adult Life and Cardiometabolic Risk Markers in Later Life; Findings from the British Regional Heart Study. PLoS ONE, 9(12), e114289.

Ke, C., Zhu, X., Zhang, Y., & Shen, Y. (2018). Metabolomic characterizationofhypertensionanddyslipidemia.Metabolomics,14(9),117.

Kuwabara, M., Kuwabara, R., Niwa, K., Hisatome, I., Smits, G., Roncal-Jimenez, C., MacLean, P., Yracheta, J., Ohno, M., Lanaspa, M., Johnson, R., & Jalal, D. (2018). Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients, 10(8), 1011.

Landi, F., Calvani, R., Picca, A., Tosato, M., Martone, A. M., Ortolani, E., Sisto, A., D’Angelo, E., Serafini, E., Desideri, G., Fuga, M. T., & Marzetti, E. (2018). Body Mass Index is Strongly Associated with Hypertension: Results from the Longevity Check-up 7+ Study. Nutrients, 10(12), 1976.

Lee, C.-Y., Lin, W.-T., Tsai, S., Hung, Y.-C., Wu, P.-W., Yang, Y.-C., Chan, T.-F., Huang, H.-L., Weng, Y.-L., Chiu, Y.-W., Huang, C.-T., & Lee, C.-H. (2016). Association of Parental OverweightandCardiometabolic Diseases and Pediatric Adiposity and Lifestyle Factors with Cardiovascular Risk Factor Clustering in Adolescents. Nutrients, 8(9), 567.

Liu, K., Colangelo, L. A., Daviglus, M. L., Goff, D. C., Pletcher, M., Schreiner, P. J., Sibley, C. T., Burke, G. L., Post, W. S., Michos, E. D., & Lloyd‐Jones, D.M.(2015).CanAntihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?: The Coronary Artery Risk Development in Young Adults (CARDIA) Study and the Multi‐Ethnic Study of Atherosclerosis(MESA). Journal oftheAmericanHeartAssociation,4(9),e002275.

Martín, V., Dávila-Batista, V., Castilla, J., Godoy, P., Delgado-Rodríguez, M., Soldevila, N., Molina, A. J., Fernandez-Villa, T., Astray, J., Castro, A., González-Candelas, F., Mayoral, J. M., Quintana, J. M., & Domínguez, A. (2015). Comparison of body mass index (BMI) with the CUN-BAE body adiposity estimator in the prediction of hypertension and type 2 diabetes. BMC Public Health,16(1),82.

Naim, M. R., Sulastri, S., & Hadi, S. (2019).GambaranHasilPemeriksaan Kadar Kolesterol Pada PenderitaHipertensidiRsudSyekh Yusuf Kabupaten Gowa. 9.

Navar-Boggan, A. M., Peterson, E. D., D’Agostino, R. B., Neely, B.,Sniderman,A.D.,&Pencina,M.J.(2015).Hyperlipidemia in EarlyAdulthood Increases Long-TermRiskofCoronaryHeartDisease.Circulation,131(5),451458.

Oliveros, E., Patel, H., Kyung, S., Fugar, S., Goldberg, A., Madan, N., & Williams, K. A. (2020). Hypertension in older adults:Assessment,management, and challenges. Clinical Cardiology,43(2),99107.

Pletcher, M. J., Vittinghoff, E., Thanataveerat, A., Bibbins-Domingo, K., & Moran, A. E. (2016). Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life:The Framingham Offspring Study. PLOS ONE, 11(5), e0154288.

Putri, L. L., Pintaningrum, Y., & Zubaidi, F. F. (2023). Hubungan Indeks Massa Tubuh (IMT)danLowDensityLipoprotein Cholesterol (LDL-C) dengan Tekanan Darah pada Pasien Poli Jantung di RSUD Provinsi NTB.LombokMedicalJournal,2(2),110120.

Shaumi, N. R. F., & Achmad, E. K. (2019).Kajian Literatur: Faktor Risiko Hipertensi pada Remaja di Indonesia. Media Penelitian danPengembanganKesehatan,29(2),115122.

Sihombing, M. (2017). Faktor yang Berhubungan dengan Hipertensi pada Penduduk Indonesia yang Menderita Diabetes Melitus (Data Riskesdas 2013). Buletin Penelitian Kesehatan, 45(1), 5364.

Tang, N., Ma, J., Tao, R., Chen, Z., Yang, Y., He, Q., Lv, Y., Lan, Z., & Zhou, J. (2022). The effects of the interaction between BMI and dyslipidemia on hypertension in adults. Scientific Reports, 12(1), 927.

Teramoto, T., Kawamori, R., Miyazaki, S., Teramukai, S., Sato, Y., Okuda, Y., & Shirayama, M. (2015). Lipid and Blood Pressure Control for the Prevention of Cardiovascular Disease in Hypertensive Patients: A Subanalysis of the OMEGA Study.JournalofAtherosclerosis and Thrombosis, 22(1), 62–75.

Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global HypertensionPracticeGuidelines. Journal of Hypertension.

Wu, H., Yu, Z., & Huang, Q. (2022). Characteristics of serum lipid levels in patients with hypertension: A hospital-based retrospective descriptive study. BMJ Open, 12(6), e054682.

Yang, Y., Dong, B., Zou, Z., Wang, S., Dong, Y., Wang, Z., & Ma, J. (2018). Association between Vegetable Consumption and Blood Pressure, Stratified by BMI,amongChineseAdolescents Aged 13–17 Years: A National CrossSectionalStudy.Nutrients,10(4),451.

Younus, A., Aneni, E. C., Spatz, E. S., Osondu, C. U., Roberson, L., Ogunmoroti, O., Malik, R., Ali, S. S., Aziz, M., Feldman, T., Virani, S. S., Maziak, W., Agatston, A. S., Veledar, E., & Nasir, K. (2016). A Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations. Mayo Clinic Proceedings, 91(5), 649–670.



  • Saat ini tidak ada refbacks.

Publisher: Universitas Malahayati Lampung

Creative Commons License
Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License

kostenlose besucherzähler